Kuchiza matenda a Microbiome: Kugwiritsa ntchito tizilombo toyambitsa matenda m'thupi pochiza matenda

• Author:
• Dzina la wolemba

  Quantumrun Foresight
• February 21, 2023

Mabakiteriya okhala m'thupi, omwe amadziwikanso kuti microbiome, amagwira ntchito yofunika kwambiri kuti munthu akhale wathanzi komanso wathanzi. Asayansi ayamba kumvetsetsa kugwirizana kovuta pakati pa thupi la munthu ndi mabakiteriya omwe amakhalapo ndi mkati mwake. Pamene kumvetsetsa uku kukukulirakulira, chithandizo chochokera ku microbiome chikhala chofala kwambiri pakuwongolera matenda. Njirayi ingaphatikizepo kugwiritsa ntchito ma probiotics kuti apititse patsogolo kukula kwa mabakiteriya opindulitsa kapena kupanga njira zochizira zomwe zimayang'aniridwa kuti athetse kusalinganika kwa ma microbiome omwe amathandizira pamikhalidwe inayake.

Njira zochizira matenda a Microbiome

Tizilombo mabiliyoni ambiri timakhala m'thupi la munthu, ndikupanga tizilombo toyambitsa matenda tomwe timakhudza ntchito zosiyanasiyana, kuyambira kagayidwe kachakudya mpaka chitetezo chokwanira. Kuchulukitsa kwa mabakiteriya posunga thanzi la anthu komanso kasamalidwe ka matenda kukuwonekera, zomwe zimapangitsa ofufuza kukhala ndi cholinga chopanga ma microbiome kuti athe kuchiza matenda angapo. Mwachitsanzo, kaphatikizidwe ka tizilombo toyambitsa matenda m'matumbo mwa makanda amatha kulosera za kuopsa kwa matenda opuma monga mphumu pambuyo pake. Ofufuza ku yunivesite ya California ku San Francisco (USCF) adapanga njira yothandizira tizilombo toyambitsa matenda mu 2021 kwa ana omwe ali pachiopsezo chachikulu kuti apititse patsogolo thanzi lawo polimbana ndi matendawa. Kafukufuku wokhudza chithandizo cha matenda otupa m'matumbo a ana (IBD) ndizothekanso pophunzira ma microbiomes am'matumbo. 

Matenda a autoimmune monga multiple sclerosis amalumikizidwanso ndi ma microbiome, ndipo mainjiniya a microbiome atha kupereka chithandizo chabwinoko kuposa njira zambiri wamba zomwe zimapondereza maselo onse oteteza thupi. Mofananamo, khungu la microbiota likugwiritsidwa ntchito pochiza odwala ndi chikanga. Kusuntha kwa mankhwala ndi metabolism m'thupi kumalumikizidwanso ndi tizilombo toyambitsa matenda, kutsegula njira zatsopano zopangira kafukufuku wolonjeza. 

Mu 2022, Hudson Institute of Medical Research ndi BiomeBank yaku Australia adalowa mgwirizano wazaka zinayi kuti aphatikize ukatswiri wawo pazamankhwala a microbiome. Mgwirizanowu cholinga chake ndikutenga kafukufuku wopangidwa ndi Hudson Institute ndikuigwiritsa ntchito pozindikira komanso kukonza machiritso a tizilombo toyambitsa matenda. BiomeBank, kampani yapachipatala pankhaniyi, ibweretsa chidziwitso ndi luso lake kuti lithandizire kumasulira kafukufukuyu kukhala ntchito zothandiza.

Zosokoneza 

Pamene kafukufuku wa microbiome akupitilira kukula, kuwunika pafupipafupi kwa ma microbiome kumatha kukhala chizolowezi chodziwika bwino pakuwunika thanzi lonse, makamaka kuyambira ali achichepere. Izi zitha kuphatikiza kuyesa kusalinganika kwa ma microbiome ndikugwiritsa ntchito njira zochizira zomwe akuyenera kuthana nazo. Chimodzi mwazinthu zofunika kwambiri pakufufuza kwa ma microbiome ndi matenda a autoimmune, omwe nthawi zambiri amakhala ovuta kuchiza bwino. 

Kafukufuku wambiri wachipatala pa microbiome amayang'ana pa ubale wake ndi matenda a autoimmune, kuphatikizapo nyamakazi ya nyamakazi, matenda a Crohn, ndi multiple sclerosis, zomwe zimakhudza anthu aku America 24 miliyoni. Ngakhale kuti majini amathandizira pakukula kwa matendawa, ofufuza amakhulupirira kuti zinthu zachilengedwe zimakhudzanso kukula kwa matendawa. Pomvetsetsa bwino ubale wapakati pa microbiome ndi matenda a autoimmune, njira zatsopano zochiritsira zitha kupangidwa. 

Pamene kuthekera kwa chithandizo cha ma microbiome kumawonekera kwambiri, ndalama zofufuzira pankhaniyi zitha kuwonjezeka. Kukula kumeneku kungayambitse kukula kwamakampani opanga ma biotechnology okhazikika pazamankhwala a microbiome pomwe, nthawi yomweyo, kuchepa kwa msika wa opanga maantibayotiki. Kuphatikiza apo, kupita patsogolo pankhani ya tizilombo toyambitsa matenda kungapangitse kuti pakhale chitukuko chamankhwala olondola komanso olondola m'malo mogwiritsa ntchito njira imodzi yokha yomwe ikugwiritsidwa ntchito pamankhwala pano. Mwa kuyankhula kwina, chithandizocho chidzagwirizana ndi mapangidwe ake enieni a microbiome m'malo mwa chithandizo chamankhwala kwa aliyense.

Zotsatira za chithandizo cha matenda a microbiome 

Zotsatira zazikulu za chithandizo cha matenda a microbiome zingaphatikizepo:

• Makhalidwe abwino a moyo pamene matenda ambiri amapeza chithandizo ndi kuchepetsa zizindikiro.  
• Kuchepetsa zochitika za chitukuko cha mabakiteriya osamva maantibayotiki pambuyo pochepetsa kugwiritsa ntchito ma antibiotic.
• Kuchulukitsa kagwiritsidwe ntchito kayezedwe ka m'matumbo a m'matumbo a microbiome kwa anthu omwe akufuna kukonza thanzi lawo.
• Kudziwitsa zambiri za kufunikira kwa thanzi la m'matumbo ndi ma microbiome zomwe zimapangitsa kusintha kwa zakudya komanso moyo.
• Kukula kwamankhwala opangidwa ndi ma microbiome omwe amabweretsa mwayi wamsika watsopano komanso kukula kwa biotechnology ndi mafakitale azamankhwala.
• Mabungwe aboma akuwunikanso malamulo ndi ndondomeko zokhudzana ndi chitukuko cha mankhwala ndi kuvomereza kuti aziwerengera chithandizo cha microbiome.
• Thandizo lokhazikitsidwa ndi ma Microbiome limakhala lothandiza kwambiri kwa anthu ena, zomwe zimapangitsa kuti pakhale kusiyana kwa kupeza chisamaliro.
• Kupita patsogolo pakutsatizana kwa ma genetic ndi matekinoloje ena okhudzana ndikuthandizira kukula kwa ma microbiome ndi kulimba mtima.
• Kupanga ndi kukhazikitsa chithandizo chamankhwala opangidwa ndi ma microbiome omwe amafuna kuphunzitsidwa ndikulemba ntchito akatswiri atsopano pantchitoyi.
• Mtengo wamachiritso opangidwa ndi ma microbiome ukhoza kukhala wokwera komanso wotsika mtengo kwa odwala ena.
• Kugwiritsa ntchito mankhwala opangidwa ndi ma microbiome kumatha kudzutsa nkhawa zamakhalidwe okhudzana ndi kusintha kwa majini komanso kusintha kwachilengedwe.

Mafunso oyenera kuwaganizira

• Ndi zoopsa ziti, ngati zilipo, zomwe zingayembekezeredwe muzamankhwala a microbiome?
• Kodi mumayembekezera kuti chithandizo choterocho chikhale chotchipa bwanji?