Mapangidwe a antibody: Pamene AI ikumana ndi DNA

• Author:
• Dzina la wolemba

  Quantumrun Foresight
• September 7, 2023

Chidule cha chidziwitso

Mapangidwe a antibody pogwiritsa ntchito generative Artificial Intelligence (AI) kupanga ma antibodies atsopano omwe amaposa achikhalidwe amatha kufulumizitsa ndikuchepetsa mtengo wopangira ma antibody. Kupambana uku kungapangitse chithandizo chamunthu kukhala chotheka komanso kupititsa patsogolo zotsatira zachipatala ndikukulitsa zokolola zachuma pochepetsa kulemetsa kwa matenda. Komabe, kupita patsogolo kotereku kwakhudzana ndi zovuta, kuphatikiza kuchotsedwa ntchito, nkhawa zachinsinsi za data, komanso mikangano yokhudzana ndi kupeza chithandizo chamunthu payekha.

Mapangidwe opangira ma antibody

Ma antibodies ndi mapuloteni oteteza omwe amapangidwa ndi chitetezo chathu chomwe chimachotsa zinthu zovulaza pomanga nawo. Ma antibodies amagwiritsidwa ntchito pafupipafupi pochiza chifukwa cha mawonekedwe awo apadera, kuphatikiza kuchepetsedwa kwa mayankho a chitetezo chamthupi komanso kukhazikika kwapadera kwa antigen. Gawo loyambirira popanga antibody mankhwala limakhudza kuzindikira molekyulu yayikulu. 

Molekyu iyi imapezeka poyang'ana malaibulale ambiri amitundu yosiyanasiyana ya ma antigen motsutsana ndi antigen yomwe mukufuna, yomwe imatha kutenga nthawi. Kukula kotsatira kwa molekyulu ndi njira yayitali. Chifukwa chake, ndikofunikira kupanga njira zofulumira zopangira ma antibody mankhwala.

Absci Corp, kampani yochokera ku New York ndi Washington, idachita bwino mu 2023 pomwe idagwiritsa ntchito mtundu wa AI wopanga ma antibodies omwe amamangiriza kwambiri ku cholandilira china, HER2, kuposa ma antibodies achire. Chosangalatsa ndichakuti pulojekitiyi idayamba ndikuchotsa zidziwitso zonse zomwe zidalipo kale, kuletsa AI kuti isamangopanga ma antibodies odziwika bwino. 

Ma antibodies opangidwa ndi Absci's AI system anali osiyana, opanda odziwika, akugogomezera zachilendo. Ma antibodies opangidwa ndi AIwa adachitanso "chirengedwe," kutanthauza kumasuka kwa chitukuko komanso kuthekera koyambitsa kuyankha kwamphamvu kwa chitetezo chamthupi. Kugwiritsiridwa ntchito koyambirira kwa AIku kupanga ma antibodies omwe amagwira ntchito bwino kapena bwino kuposa momwe thupi lathu lapangidwira kungachepetse kwambiri nthawi ndi ndalama zopangira ma antibody.

Zosokoneza

Ma antibodies opangira ma antibodies amakhala ndi chiyembekezo chamtsogolo chamankhwala, makamaka pamankhwala osankhidwa payekha. Popeza kuti chitetezo cha mthupi cha munthu aliyense chimatha kusiyanasiyana, kupanga chithandizo chamankhwala chogwirizana ndi momwe chitetezo cha mthupi chimakhalira chimatheka ndiukadaulo uwu. Mwachitsanzo, ofufuza amatha kupanga ma antibodies omwe amamangiriza ku maselo apadera a khansa mwa wodwala, ndikupereka dongosolo lamankhwala lamunthu payekha. 

Kukula kwa mankhwala achikhalidwe ndi njira yokwera mtengo, yowononga nthawi ndi kulephera kwakukulu. Generative AI imatha kufulumizitsa ntchitoyi pozindikira omwe atha kukhala ndi antibody mwachangu, kuchepetsa mtengo kwambiri komanso kukulitsa chiwongola dzanja. Kuphatikiza apo, ma antibodies opangidwa ndi AI amatha kusinthidwa ndikusinthidwa mwachangu poyankha kukana kulikonse komwe tizilombo toyambitsa matenda timapanga. Kulimba mtima uku ndikofunikira pamatenda omwe akubwera mwachangu, monga tawonera pa mliri wa COVID-19.

Kwa maboma, kukumbatira ma AI opanga ma antibody kumatha kukhudza thanzi la anthu. Sizingangofulumizitsa kuyankha pamavuto azaumoyo, komanso zitha kupangitsa kuti chithandizo chamankhwala chipezeke mosavuta. Mwachikhalidwe, mankhwala ambiri amakono ndi okwera mtengo kwambiri chifukwa cha kukwera mtengo kwa chitukuko komanso kufunikira kwa makampani opanga mankhwala kuti abweze ndalama zawo. Komabe, ngati AI ingachepetse ndalamazi ndikufulumizitsa nthawi yopangira mankhwala, ndalamazo zitha kuperekedwa kwa odwala, zomwe zimapangitsa kuti chithandizo chamankhwala chikhale chotsika mtengo. Kuphatikiza apo, kuyankha mwachangu ku ziwopsezo zomwe zikubwera zitha kuchepetsa kwambiri kukhudzidwa kwawo pagulu, kupititsa patsogolo chitetezo cha dziko.

Zotsatira za kapangidwe ka ma generative antibody

Zotsatira zazikulu za kapangidwe ka ma generative antibody zingaphatikizepo: 

• Anthu omwe amapeza chithandizo chamankhwala chokhazikika chomwe chimakhala ndi zotsatira zabwino pazaumoyo komanso nthawi ya moyo.
• Othandizira inshuwaransi yazaumoyo akuchepetsa mitengo yamtengo wapatali chifukwa chamankhwala otsika mtengo komanso zotsatira zabwino zaumoyo.
• Kuchepetsa kuchuluka kwa matenda omwe amabweretsa kuwonjezeka kwa zokolola komanso kukula kwachuma.
• Kupanga ntchito zatsopano ndi ntchito zomwe zimayang'ana panjira ya AI, biology, ndi mankhwala, zomwe zikuthandizira msika wosiyanasiyana wa ntchito.
• Maboma kukhala okonzeka kuthana ndi ziwopsezo kapena miliri zomwe zimapangitsa kuti chitetezo cha dziko chikhale cholimba komanso kuti anthu azikhala olimba.
• Makampani opanga mankhwala akusunthira ku njira zofufuzira zokhazikika komanso zogwira mtima chifukwa cha kuchepa kwa kuyesa kwa nyama komanso kugwiritsa ntchito zinthu.
• Mayunivesite ndi mabungwe amaphunziro akusintha maphunziro kuti aphatikizepo AI ndi mapangidwe a antibody, kulimbikitsa m'badwo watsopano wa asayansi amitundu yosiyanasiyana.
• Ziwopsezo zokhudzana ndi zinsinsi komanso chitetezo cha data popeza zambiri zaumoyo ndi zodziwikiratu zimafunika pakupanga ma antibodies.
• Zokhudza ndale komanso zamakhalidwe okhudzana ndi mwayi wolandira chithandizo chamunthu payekha zomwe zimapangitsa kuti pakhale mikangano yokhudzana ndi chilungamo komanso chilungamo.

Mafunso oyenera kuwaganizira

• Ngati mumagwira ntchito yazaumoyo, ndimotani momwe mapangidwe a antibody angapangire kusintha kwa odwala?
• Kodi maboma ndi ofufuza angagwirire bwanji ntchito limodzi kuti awonjezere phindu laukadaulowu?