Phekolo ea lefu la Microbiome: Ho sebelisa likokoana-hloko tsa 'mele ho alafa mafu

• Author:
• Lebitso la sengoli

  Quantumrun Ponelopele
• February 21, 2023

Libaktheria tse phelang 'meleng, tse tsejoang hape e le microbiome, li bapala karolo ea bohlokoa ho boloka bophelo bo botle le bophelo bo botle ka kakaretso. Bo-rasaense ba qala ho utloisisa litšebelisano tse rarahaneng pakeng tsa 'mele oa motho le libaktheria tse phelang ho oona le ka hare ho oona. Ha kutloisiso ena e ntse e hola, liphekolo tse thehiloeng ho microbiome li kanna tsa ata haholo taolong ea mafu. Ts'ebetso ena e kanna ea kenyelletsa ho sebelisa li-probiotics ho khothaletsa kholo ea libaktheria tse molemo kapa ho nts'etsapele liphekolo tse lebisitsoeng ho sebetsana le ho se leka-lekane ho microbiome e tlatsetsang maemong a itseng.

Boemo ba kalafo ea lefu la Microbiome

Limilione tse likete tsa likokoana-hloko li bokella 'mele oa motho, li theha microbiome e matla e amang mesebetsi e fapaneng, ho tloha metabolism ho ea ho itšireletsa mafung. Karolo e ntseng e eketseha ea libaktheria ho boloka bophelo bo botle ba batho le taolo ea mafu e ea bonahala, ho etsa hore bafuputsi ba ikemisetse ho etsa boenjiniere ba microbiome ho phekola maemo a mangata a bophelo bo botle. Mohlala, sebopeho sa likokoana-hloko tsa mala ho masea se ka bolela esale pele kotsi ea hore a ka tšoaroa ke mafu a ho hema a kang asthma hamorao. Bafuputsi Univesithing ea California San Francisco (USCF) ba thehile mokhoa oa ho kenella ka likokoana-hloko ka 2021 bakeng sa masea a kotsing e kholo ho matlafatsa bophelo ba bona khahlanong le lefu lena. Patlisiso ea kalafo ea lefu la mala a ho ruruha ho bana (IBD) le eona e ka khoneha ka ho ithuta ka li-microbiomes tsa mala. 

Mafu a ikemetseng a kang multiple sclerosis le ona a amahanngoa le microbiome, 'me boenjiniere ba microbiome bo ka fana ka phekolo e molemo ho feta mekhoa e mengata e tloaelehileng e hatellang lisele tsohle tsa' mele. Ka mokhoa o ts'oanang, microbiota ea letlalo e sebelisoa ho phekola bakuli ba nang le eczema. Ho tsamaisa lithethefatsi le metabolism 'meleng le tsona li tlameletsoe ho likokoana-hloko, ho bula mecha e mecha ea lipatlisiso tse tšepisang. 

Ka 2022, Hudson Institute of Medical Research le BiomeBank ea Australia e ile ea kena tšebelisanong ea lilemo tse 'ne ho kopanya tsebo ea bona ea kalafo ea microbiome. Tšebelisano-'moho e ikemiselitse ho nka lipatlisiso tse entsoeng ke Hudson Institute le ho li sebelisa ho sibolloa le nts'etsopele ea liphekolo tsa likokoana-hloko. BiomeBank, k'hamphani ea boemo ba bongaka lefapheng lena, e tla tlisa tsebo le boiphihlelo ba eona ho thusa ho fetolela lipatlisiso lits'ebetsong tse sebetsang.

Tšusumetso e senyang 

Ha lipatlisiso tsa microbiome li ntse li tsoela pele ho hola, litlhahlobo tse tloaelehileng tsa microbiome e kanna ea ba mokhoa o tloaelehileng oa ho lekola bophelo bo botle ka kakaretso, haholoholo ho tloha bocheng. Ts'ebetso ena e ka kenyelletsa tlhahlobo ea ho se leka-lekane ho microbiome le ho kenya tšebetsong liphekolo tse lebisitsoeng ho li rarolla. E 'ngoe ea libaka tsa bohlokoa tse shebaneng le lipatlisiso tsa microbiome ke mafu a autoimmune, ao ka tloaelo e neng e le phephetso ho alafa ka nepo. 

Palo e kholo ea lipatlisiso tsa bongaka ka microbiome e tsepamisitsoe kamanong ea eona le mathata a autoimmune, ho kenyelletsa ramatiki ea ramatiki, lefu la Crohn le multiple sclerosis, tse amang Maamerika a limilione tse 24. Le hoja liphatsa tsa lefutso li phetha karolo ea ho hlahisa mathata ana, bafuputsi ba lumela hore maemo a tikoloho a boetse a susumetsa tsoelo-pele ea mafu ana. Ka kutloisiso e betere ea kamano e teng lipakeng tsa microbiome le mathata a autoimmune, mekhoa e mecha ea kalafo e sebetsang haholoanyane e ka hlahisoa. 

Ha monyetla oa phekolo ea microbiome o ntse o bonahala haholoanyane, lichelete tsa lipatlisiso lefapheng lena li tla eketseha. Nts'etsopele ena e ka lebisa kholong ea lik'hamphani tsa biotechnology tse sebetsanang le kalafo ea likokoana-hloko, ha ka nako e ts'oanang, ho fokotseha ha karolo ea mmaraka ea baetsi ba lithibela-mafu. Ho feta moo, tsoelopele lefapheng la microbiome ea motho e kanna ea lebisa nts'etsopele ea liphekolo tsa moetlo le tse nepahetseng ho fapana le mokhoa o lekanang le o mong o sebelisoang hona joale bongaka. Ka mantsoe a mang, liphekolo li tla etsoa ho latela litlolo tsa motho ka mong ho fapana le kalafo e akaretsang bakeng sa motho e mong le e mong.

Liphello tsa phekolo ea lefu la microbiome 

Litlamorao tse pharalletseng tsa kalafo ea lefu la microbiome li ka kenyelletsa:

• Maemo a bophelo a ntlafetseng ha mafu a mangata a ntse a fumana phekolo le ho fokotsa matšoao.  
• Ho fokotseha ha maemo a nts'etsopele ea libaktheria tse hananang le lithibela-mafu ka mor'a ho fokotseha ha tšebeliso ea lithibela-mafu.
• Keketseho ea ts'ebeliso ea liteko tsa tlhahlobo ea lapeng ea gut microbiome bakeng sa batho ba ratang ho ntlafatsa bophelo ba bona.
• Keketseho ea tlhokomeliso ea bohlokoa ba bophelo bo botle ba mala le microbiome e lebisang liphetohong tsa khetho ea lijo le mokhoa oa bophelo.
• Nts'etsopele ea liphekolo tse thehiloeng ho li-microbiome tse hlahisang menyetla e mecha ea mmaraka le kholo ea biotechnology le indasteri ea meriana.
• Mekhatlo ea 'muso e ntlafatsang melaoana le maano a amanang le nts'etsopele ea lithethefatsi le tumello ea ho ikarabella bakeng sa kalafo e thehiloeng ho microbiome.
• Liphekolo tse thehiloeng ho microbiome li sebetsa hantle haholo ho batho ba itseng, e leng se lebisang ho se tšoane ha phihlello ea tlhokomelo.
• Tsoelopele ea tatelano ea liphatsa tsa lefutso le mahlale a mang a amanang le ona ho ts'ehetsa kholo ea microbiome le botsitso.
• Ntlafatso le ts'ebetsong ea liphekolo tse thehiloeng ho microbiome tse hlokang koetliso le ho hira litsebi tse ncha lefapheng lena.
• Litsenyehelo tsa liphekolo tse thehiloeng ho microbiome li kanna tsa ba holimo mme tsa fumaneha feela ho bakuli ba bang.
• Tšebeliso ea liphekolo tse thehiloeng ho microbiome e ka hlahisa matšoenyeho a boitšoaro a amanang le phetoho ea liphatsa tsa lefutso le ho qhekella ha litsamaiso tsa tlhaho.

Lipotso tse lokelang ho nahanoa

• Ke likotsi life, haeba li teng, tse ka lebelloang liphekolong tsa microbiome?
• U lebeletse hore liphekolo tse joalo li boloke chelete e kae?