Imithi yokwelapha ye-psychedelic ethuthukisiwe: Ukwelapha izidakamizwa ukuze udale izindlela zokwelapha ezihamba phambili

• About the Author:
• Igama lomlobi

  I-Quantumrun Foresight
• February 10, 2023

Lapho kwenziwa isampula yezidakamizwa zokuzijabulisa, wonke umuntu usabela ngendlela ehlukile ngenxa yofuzo oluhlukahlukene. Kodwa-ke, amafemu e-biotech manje adala izindlela zokwelapha ze-psychedelic eziklanyelwe ukukhomba uchungechunge lwezimo zempilo yengqondo ngokusekelwe kufuzo. 

Umongo we-psychedelics olungiselelwe

Izidakamizwa ze-Psychedelic zivame ukuxhunyaniswa nokusetshenziswa kwezidakamizwa ezingekho emthethweni, ukuzijabulisa. Ngakho-ke, ucwaningo oluningi lwesayensi nezokwelapha ngalezi zinto lugxile emiphumeleni emibi engaba khona yokuhlukumeza. Yize kusekuningi okungaziwa ngezidakamizwa ze-psychedelic, ucwaningo lwango-2020 olushicilelwe kujenali ye-Psychological Medicine luhlonze izinzuzo ezingaba khona zokwelapha zezinto ezifana ne-Ayahuasca, i-ketamine, i-LSD, i-MDMA, noma i-psilocybin yezimo zengqondo ezihlanganisa ukudangala kanye nesifo sokucindezeleka sangemva kwe-traumatic (PTSD). ). Lawa ma-psychedelics abonisa imiphumela ethembisayo ezigulini ezingakaphenduli ekwelashweni okujwayelekile.

Ngenxa yalokhu kwamukelwa okukhulayo kwezidakamizwa ze-psychedelic njengezindlela zokwelapha zengqondo ezingaba khona, amazwe amaningana agunyaze ukusetshenziswa kwazo ngaphansi kwemithamo elawulwayo. Amafemu e-Biotech nawo abelokhu ethuthukisa izindlela zokuqonda kangcono i-psychedelic ngayinye, izici zayo ezihlukile, nokuthi zingabhekana kanjani nezimo ezithile zengqondo ukuze kwandiswe izinzuzo zalokhu kuthuthukiswa. 

Ngokocwaningo lwango-2017 olwanyatheliswa kuyi-Neuroscience & Biobehavioral Reviews iphephabhuku, izidakamizwa ze-psychedelic, njenge-ketamine, zivame ukutholakala zinciphisa imicabango yokuzibulala ezigulini ezifuna ukuzibulala. I-Psilocybin, imvamisa esikalini esisodwa, idala imiphumela ebalulekile neyesikhathi eside ye-antidepressant ezigulini ezingaphenduli kwezinye izindlela zokwelapha, ngokusho kwe-Biological Psychiatry. Lokhu okutholakele kusikisela ukuthi izidakamizwa ezenzelwe amaphrofayili athile ofuzo kanye nezimo zingasebenza isikhathi eside.

Umthelela ophazamisayo

Ngo-2021, eNew York-based Mind Medicine (MindMed) yamemezela izinhlelo zayo zokuthuthukisa ukwelashwa kwe-MDMA kokukhathazeka komphakathi kanye ne-autism spectrum disorder (ASD). Le nkampani yakha iphothifoliyo yokuthuthukisa izidakamizwa yenoveli yokwelapha esekelwe ezintweni ze-psychedelic, okuhlanganisa i-psilocybin, i-LSD, i-MDMA, i-DMT, kanye nokuphuma kwe-ibogaine i-18-MC. I-MindMed ithe ifuna ukuthola izindlela zokwelapha ezibhekana nokulutheka nesifo sengqondo. 

Okwamanje azikho izindlela zokwelapha ezigunyaziwe zezimpawu eziwumongo ze-ASD, okugqamisa isidingo esibalulekile esingahlangatsheziwe semithi yokwelapha emisha kule ndawo. Izindleko zomnotho ze-ASD e-US zibikezelwa ukuthi zizofinyelela ku-USD $461 billion ngo-2025, ngokusho kwe-MindMed. Phakathi naleso sikhathi, amaphesenti angu-12 omphakathi jikelele ahlangabezana ne-Social Anxiety Disorder esikhathini esithile ekuphileni kwawo, ngokusho kweNational Institute of Mental Health, egcizelela isidingo sokungenelela okwengeziwe.

Ngo-2022, i-ATAI Life Sciences yaseJalimane yamemezela ukuthi yenze inqubekelaphambili enkulu ekuthuthukiseni ukwelashwa kwengqondo ngemithi ye-psychedelic. Enye yalezi zintuthuko ukwelashwa kwe-psilocybin ye-COMP360 yabantu abanokucindezeleka okungazweli ekwelashweni. Ukwengeza, inkampani ibheka kabusha i-PCN-101 (ingxenye ye-ketamine) njenge-antidepressant esebenza ngokushesha engathathwa ekhaya. Kuze kube manje, lezi zifundo zibonisa ukuthi kuzoba nokuncipha okusheshayo kwezimpawu zokucindezeleka phakathi nehora elilodwa ngemva kokuphathwa, futhi kungase kuhlale izinsuku ezingafika kweziyisikhombisa.

I-ATAI iphinde ithuthukise izindlela zokwelapha i-PTSD isebenzisa okuphuma kokuphuma ku-MDMA. Ukwengeza, inkampani engaphansi kwenkampani, i-Revixla Life Sciences, ifunda ukuthi i-Salvinorin A, inhlanganisela yemvelo ye-psychedelic, ingaphatha kanjani izinkinga ezihlukahlukene zempilo yengqondo. I-ATAI isivele iqale izivivinyo zayo eziningi zomtholampilo ngo-2022.

Imithelela yama-psychedelics athuthukisiwe

Imithelela ebanzi yama-psychedelics athuthukisiwe ingafaka: 

• Ukuqala kwe-Biotech kuya ngokuya kugxila emakethe yokwelashwa kwezidakamizwa ze-psychedelic, ngokubambisana namanye ama-biotech kanye nezikhungo zocwaningo.
• Ukwemukelwa okwengeziwe kwezidakamizwa zokungcebeleka njengezindlela zokwelapha ezisemthethweni, okunciphisa ukucwaswa okuhambisana nazo.
• Imboni yezidakamizwa ze-psychedelic ikhula ngokushesha phakathi nawo wonke ama-2020, iqhutshwa ikakhulukazi izimakethe ezithuthukisiwe zezidakamizwa nezokuphila okunethezeka.
• Ohulumeni abaqapha ukuthi kwenziwa kanjani izifundo nokuhlolwa kwe-psychedelics ukuze kuqinisekiswe ukuthi zihlala zisemthethweni futhi ziziphatha kahle. Kuye ngemiphumela, kungase kuphasiswe umthetho owengeziwe ovumela ukusetshenziswa kwezidakamizwa ezinjalo endaweni elawulwayo noma ngemithamo elinganiselwe.
• Ukufiphala komugqa phakathi kokusebenzisa izidakamizwa zokungcebeleka kwezokuzijabulisa nezomuthi, okungase kubangele ukunqwabelanisa okuthile nokudlula umthamo.

Imibuzo ongaphawula ngayo

• Ngabe imboni yezidakamizwa ze-psychedelic izozuza kanjani futhi emakethe yezidakamizwa elungiselelwe?
• Uma uke wazama izindlela zokwelapha ezisekelwe emithini ye-psychedelic, ziphumelele kangakanani?