Nerve coolers: Freezing the hurt away

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  Quantumrun Foresight
• April 9, 2024

Insight summary

Researchers have developed a new, drug-free method for pain relief using tiny, implantable devices that cool nerves. These devices, thinner than a sheet of paper and made from flexible materials, use a cooling method similar to sweating to provide targeted pain relief without the side effects of traditional painkillers. This advancement could change postoperative care, reduce healthcare costs, and shift the medical device industry towards more personalized and non-addictive pain management solutions.

Nerve coolers context

Soft, miniature implantable cooling devices designed to encircle nerves have emerged as a novel approach to pain relief without relying on pharmaceuticals. This technology, spearheaded by Northwestern University, operates on the principle of analgesic nerve cooling. By applying cold directly to a nerve, similar to the effect of an ice pack on a sore muscle or joint, these devices aim to block pain signals. With acute pain affecting one in five adults worldwide and the overuse of opioids contributing to a public health crisis, this approach could significantly alter pain management strategies.

The device significantly differs from conventional nerve-cooling technologies, which are generally bulky, require considerable power, and cool extensive tissue areas, potentially leading to tissue damage and inflammation. In contrast, this invention is as thin as a sheet of paper, crafted from soft, flexible materials that conform closely to the body's internal structures. Utilizing a process akin to sweat evaporation for cooling, this device incorporates microfluidic channels that allow a coolant, perfluoropentane—a substance already approved for medical use—to evaporate and cool the nerve rapidly. This method ensures targeted, efficient pain relief with minimal risk of adverse effects.

Looking forward, this research could redefine postoperative pain management. Integrating these devices during surgical procedures could localize pain relief. Moreover, the device's bioresorbable nature, allowing it to dissolve harmlessly in the body, eliminates the need for additional surgeries to remove it. While not designed to address chronic pain, this technology represents a promising step toward safer, more effective pain management solutions.

Disruptive impact

By providing an alternative to traditional painkillers, these devices can reduce dependency on opioids, addressing a critical public health issue. For individuals, this means access to safer pain relief methods that carry a lower risk of addiction and side effects. Hospitals and healthcare providers may see a decrease in complications related to pain management, leading to shorter hospital stays.

Companies in the medical device sector could find new opportunities for innovation and market expansion. The development and refinement of bioresorbable technology for nerve cooling will likely spur further research and product development, opening up avenues for advancements in other areas of medical treatment. As companies invest in these technologies, the healthcare industry may shift towards more personalized and efficient care solutions. This trend also highlights the importance of interdisciplinary collaboration, merging expertise in biomedical engineering, material science, and clinical practice to address complex health challenges.

For governments and policymakers, the emergence of drug-free pain relief technologies presents an opportunity to revise healthcare policies and funding priorities. By supporting research and development in this field, they can facilitate the introduction of new treatments that can potentially transform patient care. Furthermore, this trend could lead to significant economic benefits, including reduced healthcare costs associated with managing drug addiction and overdose.

Implications of nerve coolers

Wider implications of nerve coolers may include: 

• Increased demand for biomedical engineers and specialists, creating new job opportunities in the medical technology sector.


• Healthcare systems experiencing lower costs associated with treating addiction and overdose, enabling the reallocation of resources to other areas of need.


• Patients gaining more control over their pain management, leading to higher satisfaction with postoperative care and overall treatment experiences.


• Medical device companies shifting focus toward drug-free technologies, diversifying their product lines and research areas.


• Policy makers revising healthcare regulations to support the adoption of non-pharmacological pain management devices, reflecting changing medical practices.


• An expansion in the use of microfluidics and flexible electronics beyond pain management, spurring advances in other medical devices and applications.


• Insurance companies adjusting coverage policies to include implantable nerve-cooling devices, making them more accessible to a broader range of patients.


• A cultural shift towards prioritizing non-addictive pain management methods, influencing public attitudes towards drug use and medical care.

Questions to consider

• How could this technology influence the development of new medical devices and treatments for other conditions?


• How could the reduction in opioid use due to these devices impact public health and society over the next decade?